8. Inherited Diseases Affecting the Liver

Refer to WBDSG entry for the condition.
If there is no specific entry, must not donate

a) If the donor is well and stable on treatment for Wilson’s Disease, accept.

b) If the donor has Gilbert’s Syndrome and is not visibly jaundiced, accept

c) For other conditions, see the Inherited Diseases entry

Inherited Diseases
Haemochromatosis

Wilson’s disease is caused by an excessive accumulation of copper in the liver and other organs. e.g. brain. If diagnosed and treated early with chelating agents, such as Penicillamine and Trientine, and avoidance of high copper foods, the prognosis is good and individuals can lead a normal life. If there is uncertainty about the donor’s health or treatment, refer to a Designated Clinical Support Officer.

Alpha-1-antitrypsin deficiency can occasionally cause liver disease in adults. This may lead to liver failure and the need for liver transplantation.

Gilbert's syndrome is an inherited defect in bilirubin metabolism. It is harmless but can cause jaundice (yellowing of the whites of the eyes). Blood banks are unlikely to use blood that appears jaundiced. This means any visibly jaundiced donation is likely to be wasted.