JPAC Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee

5. Individuals undergoing Hepatitis B immunisation

Obligatory

a) Known Exposure:
Must not donate.


b) No Known Exposure:
Must not donate if:
Less than seven days since the most recent dose of vaccine was given.

Discretionary

a) Known Exposure:
If it is more than 4 months from the date of exposure, samples can be taken for HBV and anti-HBc testing. No donation should be taken.


b) No Known Exposure:
If it is more than 7 days from the date of the most recent dose of vaccine, accept

Post-session review of results

a) If the donor is negative for HBV and Anti-HBc, the donor can be accepted. Additional hepatitis B testing is not required for future donations unless the donor discloses a new risk.


b) If any of HBsAg, anti-HBc or HBV DNA are positive, refer to Section 1: Active or recovered hepatitis B infection

See if Relevant

Hepatitis A – 4. Immunisation
Immunoglobulin Therapy

Additional Information

Specific HBV immunoglobulin may be used in the management of individuals who have been exposed to hepatitis B. 
Administration of hepatitis B vaccine can lead to low level reactivity in HBsAg screening assays. For this reason, donors must be deferred until at least 7 days after receiving a dose of vaccine, even if they have not been exposed to HBV.
Hepatitis B vaccine is sometimes given in a combined vaccine with hepatitis A vaccine.