Immunoglobulin Therapy

1. Must not donate if:
a) After January 1st 1980 the donor has been treated with intravenous or subcutaneous human immunoglobulin.

b ) The donor has received multiple intramuscular injections of high dose immunoglobulin.

c ) Immunosuppressed.

2. Donors with recovered immunodeficiency:
Refer to a 'Designated Clinical Support Officer'.

a) If the intravenous or subcutaneous human immunoglobulin was given before 1980, accept.

b) If given routine ante- or post-natal anti-D immunoglobulin only(even if received more than one dose), accept.

c) If single dose prophylactic immunoglobulin has been given, accept.

If treated with intravenous or subcutaneous human immunoglobulin:
Transfusion

Hepatitis A - 4. Immunisation
Hepatitis B - 4. Immunisation
Immunodeficiency
Prion Associated Diseases
Rabies - 2. Immunisation - Post Exposure
Tetanus - 2. Immunisation

Immunoglobulin used before 1980 is unlikely to be affected by vCJD (a prion associated disease).

Single dose intramuscular immunoglobulin is unlikely to pose a significant risk of transmitting vCJD.

This entry reflects guidance from the former Committee on the Microbiological Safety of Blood Tissues and Organs of the Department of Health.

Link updated from 'Immunosuppression' to 'Immunodeficiency' in the 'See if Relevant' section.

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