JPAC Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee
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Known Exposure

Obligatory

Must not donate.

Discretionary

If more than 12 months from immunization obtain history and blood samples and:
Refer to a Designated Medical Officer.

Additional Information

Only accept if negative for all markers (i.e. HBsAg, HBV-DNA and HB core antibody) or, HB core antibody positive, HBsAg negative and HBV-DNA negative.

Immunization post exposure may be with specific anti-HB immunoglobulin as well as with HBsAg.

May be combined with hepatitis A immunization.

Reason for Change

To remove the requirement for anti-HBs levels to be >100 iu/l for acceptance of stem cell donations from donors who are anti-HBc-positive provided the HBV DNA result is negative.