JPAC Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee

Options for Human T-Lymphotropic Virus (HTLV) screening with the UK Blood Services (updated October 2015)

Prepared by the UK BTS Joint Professional Advisory Committee’s (JPAC)  HTLV Working Group

Update information – 6 October 2015

Subsequent to the SaBTO meeting of 1st September 2015, the cost-effectiveness analysis reported in Section 10 of the “Options for Human T-Lymphotropic Virus (HTLV) screening within the UK Blood Services” paper (item 5) has been updated to incorporate members’ requests:

  1. A new column have been added to table 10.2 giving the chance of a TTI in terms of the number of issues, e.g. 1 TTI per x issues, and similarly a new column has been added to table 10.5 for the chance of associated disease (requested by Dr Lorna Williamson).
  2. An additional section covering the rates of vertical and sexual transmission of HTLV from TTI infected individuals has been added to the results section (requested by Professor Richard Tedder).

In addition to these requested updates, better estimates have been implemented for the number of infected and tested issues, and a minor error in the QALY calculation corrected.  While this has impacted some of the more extreme values reported, the relative relationships and conclusions of the original report remain the same.