JPAC Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee

4. Autoimmune Liver Disease

Includes

Autoimmune Hepatitis (AIH), Primary Biliary Cholangitis (PBC) and Primary Sclerosing Cholangitis (PSC)  

Obligatory

Must not donate if:

  • under active investigation or treatment, or
  • associated with Inflammatory Bowel Disease  
Discretionary

a) If well, even if on treatment to control symptoms. e.g. Cholestyramine (Questran) or Ursodeoxycholic acid (also known as Ursodiol), accept.


b) If well and taking treatment to suppress the condition, refer to the Autoimmune Disease entry

See if Relevant

Autoimmune Disease
Hepatitis
Steroid Therapy 

Additional Information

Autoimmune liver disease in its early stages may be asymptomatic or present with mild symptoms such as itchy skin (pruritis) and fatigue. The donor may require no treatment or treatment for symptom control only for an extended period.


Autoimmune liver disease may be diagnosed during investigation for other conditions, especially other autoimmune conditions Treatment to suppress these diseases may include steroids, Azathioprine and other immunosuppressants. If there is doubt about the diagnosis and treatment, refer to a DCSO.