JPAC Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee

Conn's Syndrome

Excludes

Secondary Hyperaldosteronism 

Obligatory

Must not donate  

Discretionary

If donor has undergone surgery for a benign adrenal tumour (adenoma), the donor is fully recovered, has been discharged from follow up and is not on medication for Conn’s syndrome, accept. 

See if Relevant

Blood Pressure – high 
Diuretics 

Additional Information

Conn’s syndrome (primary hyperaldosteronism) is caused by overproduction of aldosterone in the adrenal cortex. Aldosterone is a hormone that regulates potassium and sodium levels as well as fluid balance in the body thereby maintaining blood volume and blood pressure, helping the body to control stress and maintain a steady metabolic state and normal electrolyte balance. 
Secondary hyperaldosteronism is caused by increased adrenal production by medical conditions outside the adrenal gland which stimulates the renin- angiotensin- aldosterone mechanism.