JPAC Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee

SRI Publications

The Systematic Review Initiative has so far completed over 70 systematic reviews covering many different aspects of transfusion medicine. Our reviews are all produced using strict methodological criteria in accordance with best evidence-based practice, and have been published in a wide variety of journals, with approximately half appearing in The Cochrane Library. Please view our Publications pages via the left-hand menu for full details of our reviews with full text links.

Recently completed systematic reviews include:

  • Restrictive versus liberal transfusion strategies in cardiovascular disease
  • Transfusion interventions in critical bleeding requiring massive transfusion
  • Stem cell treatment for acute myocardial infarction [update]
  • Cell therapy for heart failure
  • Electronic decision support for the appropriate use of blood
  • Restrictive versus liberal red cell transfusion for patients with myelodysplasia, aplastic anaemia, and other congenital bone marrow failure disorders
  • Measures to reduce fainting or syncope in blood donors
  • Transfusion of fresher versus older red blood cells for all conditions
  • Platelets:   
    • platelet transfusions prior to lumbar punctures or epidural anaesthesia in patients with thrombocytopenia
    • prophylactic versus therapeutic platelet transfusion [update]
    • different platelet thresholds to guide prophylactic platelet transfusion in a variety of settings
    • platelet dose A versus platelet dose B
    • prophylactic platelets versus alternative agents.

Recent publications include:

Docherty AB, O'Donnell R, Brunskill S, Trivella M, Doree C, Holst L, et al.
Effect of restrictive versus liberal transfusion strategies on outcomes in patients with cardiovascular disease in a non-cardiac surgery setting: systematic review and meta-analysis.
BMJ 2016;352:i1351.

Hall DP, Estcourt LJ, Doree C, Hopewell S, Trivella M, Walsh TS.
Plasma transfusions prior to insertion of central lines for people with abnormal coagulation.
Cochrane Database of Systematic Reviews 2016; (9):CD011756.

Estcourt LJ, Stanworth SJ, Doree C, Hopewell S, Trivella M, Murphy MF.
Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after chemotherapy or stem cell transplantation.
Cochrane Database of Systematic Reviews 2015;(11):CD010983.

Estcourt LJ, Stanworth S, Doree C, Trivella M, Hopewell S, Blanco P, Murphy MF.
Different doses of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation.
Cochrane Database of Systematic Reviews 2015;(10):CD010984.