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# Pre- and post-exposure prophylaxis (PrEP, PEP) for HIV prevention - Whole blood and components

## Essential information

Obligatory

  Must not donate if:

  1. The donor has taken oral pre-exposure prophylaxis (PrEP) or post-exposure prophylaxis (PEP) in the previous 3 months.
  2. The donor has received an injection for PrEP in the previous 2 years.

  Assess any donor using PrEP or PEP for blood safety risks relating to sexual activity.

Discretionary

  If:

  - It is over 3 months since the donor last used oral PrEP or PEP, and/or
  - It is over 2 years since the donor last received an injection for PrEP, and
  - There is no other blood safety risk,

  accept.

## Supporting information

See if relevant
  - Blood safety
  - HIV
  - Non-consented exposure to human body fluids
Additional information

  Pre-exposure prophylaxis (PrEP):

  The use of PrEP to prevent HIV is increasing. Individuals taking PrEP are unlikely to be eligible to donate due to criteria within the Blood safety entry. However, PrEP is also available via private prescription and/or online pharmacies and may be used by individuals who would not otherwise be deferred.

  PrEP is normally given in tablet form but longer-acting injectable PrEP, e.g. cabotegravir (Apretude??), may also be used in individuals who are not suitable for oral medication. Cabotegravir injections are given on an 8-weekly basis to ensure adequate HIV protection. Low levels of cabotegravir can be detected for many months in treated individuals, even after injections have been stopped.

  Use of PrEP may interfere with testing for HIV by delaying seroconversion or giving unclear results in a positive donor. For this reason, it is important that donors who have taken oral PrEP in the previous 3 months, or injected PrEP in the previous 2 years, are not accepted to donate, even if they do not have another blood safety risk.

  Post-exposure prophylaxis (PEP):

  PEP has a similar mechanism of action to PrEP and may also interfere with testing results. In the UK, PEP is prescribed to people who have been exposed to someone who may have HIV. This includes sexual activity or a needle stick injury. Donors who have received PEP will usually be ineligible to donate for the same reason they were given PEP.

  If the underlying reason for taking PrEP or PEP warrants a longer deferral period, this should be applied.

Reason for change:
  Addition of a two-year deferral for recipients of injectable PrEP.
Version details:

  WB-DSG Edition 203 Release 77 (18 July 2025)

BETA

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