|
Fresh frozen plasma |
mean |
sd |
95%CI |
range |
|
Number of donors per pack |
1 |
|
|
|
|
Volume ml |
273 |
± 17 |
277–279 |
240–300 |
|
Plasma ml |
220 |
|
|
|
|
Anticoagulant ml |
50 |
|
|
|
|
Fibrinogen g/l |
20–50 |
|
|
|
|
Fibrinogen mg per pack estimated |
|
|
554–1395 |
|
|
Factor VIII c IU/ml (in > 75% packs) |
> 0.7 |
|
1.03–1.06 |
|
|
Other coagulation factors |
variable |
|
|
|
|
Other plasma proteins |
< normal plasma |
|
|
|
|
Storage |
2 years at -30°C |
|
|
|
|
Methylene blue plasma1 |
|
Number of donors per pack |
1 |
|
|
|
|
Volume ml |
232 |
± 18 |
|
|
|
Plasma ml |
220 |
|
|
|
|
Anticoagulant ml |
50 |
|
|
|
|
Factor VIII c IU/ml (in > 75% packs) |
> 0.7 |
|
|
|
|
Storage |
2 years at -30°C |
|
|
|
|
Solvent-detergent plasma1 |
|
Number of donors per pack |
380–2500 |
|
|
|
|
Volume ml |
200 |
|
|
|
|
Fibrinogen g/l |
27 |
|
|
|
|
Factor VIII c IU/ml (in > 75% packs) |
> 0.5 |
|
|
|
|
Storage |
1 year at -30°C |
|
|
|
|
Compatibility |
FFP should be ABO compatible to avoid risk of haemolysis caused by donor anti A or anti B
FFP does not need to be RhD matched |
|
Dosing guide |
12–15 ml/kg would typically increase fibrinogen levels by about 1 g/l |
|
Administration |
Use standard blood administration set
Rapid infusion may increase risk of acute reactions |
|
Cautions |
Risk of volume overload
Rapid infusion may increase risk of adverse reaction |
|
Infection risk |
Pathogen reduction should reduce any risk due to micro-organisms
Non-UK plasma should reduce risk of vCJD |
|
Source: NBS and SNBTS routine QA data
Note:
1More detail of SDFFP and MBFFP is available at www.transfusionguidelines.org.uk |