|
From whole blood donations: platelets from 4 or 5 donations constitute an adult therapeutic dose (ATD)
From apheresis: 1 donor collection provides 1 to 3 ATDs |
|
From whole blood
(pool of 4 donations is 1 adult dose) |
mean |
sd |
95% CI |
range |
|
Number of donors |
4 |
|
|
|
|
Volume ml |
310 |
± 33 |
317–321 |
250–400 |
|
Platelets x 109
(at least 240 x 109) |
330 |
± 50 |
329–332 |
180–400 |
|
Plasma ml |
250 |
|
|
|
|
Anticoagulant ml |
60 |
|
|
|
|
White cells per unit |
0.3 x 106 per pack |
|
|
|
|
From apheresis |
mean |
sd |
95% CI |
range |
|
Number of donors |
1 |
|
|
|
|
Volume ml |
215 |
± 53 |
206–207 |
180–300 |
|
Platelets x 109 |
290 |
± 45 |
289–291 |
180–400 |
|
Plasma ml |
180 |
|
|
|
|
Anticoagulant ml |
35 |
|
|
|
|
White cells per unit |
0.3 x 106per pack |
|
|
|
|
Storage |
5 days at 22 ± 2°C on a special agitator rack (may be extended to 7 days if system is validated and in conjunction with bacterial testing) |
|
Compatibility requirement |
Preferably ABO and RhD identical with patient |
|
Dosing guide |
For a 70 kg adult, 1 adult dose typically gives an immediate rise in platelet count of 20–40 x 109 ml |
|
Administration |
Infuse through a standard blood administration set or a platelet infusion set – use a fresh set when administering each infusion of platelets |
|
Cautions |
RhD negative females with potential for childbearing must be given RhD negative platelets to avoid risk of Rh sensitisation
Plasma in the platelets can cause an ABO incompatibility reaction, TRALI or allergic reaction |
|
Source: NBS and SNBTS routine QA data
|