Contents
ContentsIntroductionGeneral informationPurpose of the handbookTerms for blood productsClinical governanceNew legislationGuidance on basic standards for clinical transfusionImportant changes since the third editionBlood products and transfusion proceduresProduction and labelling of blood products and plasma derivativesSummary information about blood products and haemostatic agentsRed cellsPlateletsPlasma cryoprecipitate and granulocytesLabelling of blood componentsPlasma derivativesDrugs promoting haemostasisBasics of red cell immunology and compatibility testingABO blood groups and antibodiesABO-incompatible red cell transfusionDiagnosis and management of severe acute transfusion reactionsRhD antigen and antibodyOther red cell antigen/antibody systemsCompatibility proceduresPretransfusion and transfusion proceduresProcedures for ordering bloodPretransfusion checksAdministration of blood componentsClinical transfusion: surgery and critical illnessGood blood managementTransfusion in major haemorrhagePlanned surgeryPreoperative managementIntra- and post-operative managementMajor haemorrhage: surgery, trauma, obstetrics and gastrointestinalUse of blood components in the patient who is bleedingManagement of a bleeding patient who has received fibrinolytics or platelet inhibitorsCardiac surgeryLiver transplantation and resectionCritical illnessGastrointestinal haemorrhage: haematemesis and melaenaClinical transfusion in the medical settingAnaemiaRed cell transfusion in anaemiaHaemoglobinopathiesAnaemia in chronic renal failureCongenital haemostatic disordersBone marrow failure due to disease, cytotoxic therapy or irradiationImmunological disorders - use of immunoglobulinTherapeutic plasma exchangeImmunoglobulin for prevention of infectionTransfusion in antenatal obstetric and neonatal careObstetric haemorrhageHaemolytic disease of the newbornTransfusion of the newborn infantTransfusion for neonates − principlesEquipment for paediatric transfusionExchange transfusionEpoetin in neonatesThrombocytopenia and platelet transfusionNeonatal alloimmune thrombocytopeniaUse of fresh frozen plasma in neonatesAdverse effects of transfusionReportingAcute complications of transfusionDelayed complications of transfusionInfections transmissible by transfusionNumber of adverse transfusion events and reactionsInforming patientsInformation about donation by relatives or friends (directed donation)Information for patients who do not accept transfusionsList of figuresList of tablesAuthors and reviewersChanges and updates to the Handbook of Transfusion Medicine, 4th edition published January 2007References
Introduction
General information
Purpose of the handbook
Terms for blood products
Clinical governance
New legislation
Guidance on basic standards for clinical transfusion
Important changes since the third edition
Blood products and transfusion procedures
Production and labelling of blood products and plasma derivatives
Summary information about blood products and haemostatic agents
Red cells
Platelets
Plasma cryoprecipitate and granulocytes
Labelling of blood components
Plasma derivatives
Drugs promoting haemostasis
Basics of red cell immunology and compatibility testing
ABO blood groups and antibodies
ABO-incompatible red cell transfusion
Diagnosis and management of severe acute transfusion reactions
RhD antigen and antibody
Other red cell antigen/antibody systems
Compatibility procedures
Pretransfusion and transfusion procedures
Procedures for ordering blood
Pretransfusion checks
Administration of blood components
Clinical transfusion: surgery and critical illness
Good blood management
Transfusion in major haemorrhage
Planned surgery
Preoperative management
Intra- and post-operative management
Major haemorrhage: surgery, trauma, obstetrics and gastrointestinal
Use of blood components in the patient who is bleeding
Management of a bleeding patient who has received fibrinolytics or platelet inhibitors
Cardiac surgery
Liver transplantation and resection
Critical illness
Gastrointestinal haemorrhage: haematemesis and melaena
Clinical transfusion in the medical setting
Anaemia
Red cell transfusion in anaemia
Haemoglobinopathies
Anaemia in chronic renal failure
Congenital haemostatic disorders
Bone marrow failure due to disease, cytotoxic therapy or irradiation
Immunological disorders - use of immunoglobulin
Therapeutic plasma exchange
Immunoglobulin for prevention of infection
Transfusion in antenatal obstetric and neonatal care
Obstetric haemorrhage
Haemolytic disease of the newborn
Transfusion of the newborn infant
Transfusion for neonates − principles
Equipment for paediatric transfusion
Exchange transfusion
Epoetin in neonates
Thrombocytopenia and platelet transfusion
Neonatal alloimmune thrombocytopenia
Use of fresh frozen plasma in neonates
Adverse effects of transfusion
Reporting
Acute complications of transfusion
Delayed complications of transfusion
Infections transmissible by transfusion
Number of adverse transfusion events and reactions
Informing patients
Information about donation by relatives or friends (directed donation)
Information for patients who do not accept transfusions
List of figures
List of tables
Authors and reviewers
Changes and updates to the Handbook of Transfusion Medicine, 4th edition published January 2007
References